Two sample MR report

Telomere_length against IDP dMRI TBSS FA Cingulum cingulate gyrus L

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0958976	0.1206497	0.4355964
Weighted median	23	-0.1600392	0.0570109	0.0049979
Inverse variance weighted	23	-0.1250131	0.0461427	0.0067431
Simple mode	23	-0.1695920	0.1034919	0.1155000
Weighted mode	23	-0.1493859	0.0680778	0.0390628

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.33451	21	0.0854693
Inverse variance weighted	30.43380	22	0.1082964

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017878	0.0068193	0.7957427

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012299	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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