Two sample MR report

Telomere_length against IDP dMRI TBSS FA Cerebral peduncle R

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.2572811	0.1003842	0.0181247
Weighted median	23	-0.1723252	0.0548523	0.0016801
Inverse variance weighted	23	-0.1775045	0.0392313	0.0000061
Simple mode	23	-0.1154606	0.0870057	0.1981025
Weighted mode	23	-0.1462176	0.0638657	0.0320140

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.58229	21	0.7360947
Inverse variance weighted	17.32771	22	0.7450214

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0048987	0.0056739	0.3976838

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011453	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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