Two sample MR report

Telomere_length against IDP dMRI TBSS FA Cerebral peduncle L

Date: 23 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1648835	0.1086456	0.1440198
Weighted median	23	-0.1426828	0.0577470	0.0134801
Inverse variance weighted	23	-0.1963466	0.0415814	0.0000023
Simple mode	23	-0.1230432	0.0954701	0.2108509
Weighted mode	23	-0.1230432	0.0667085	0.0786197

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.59868	21	0.2649634
Inverse variance weighted	24.71463	22	0.3109153

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.001932	0.0061409	0.7561582

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015078	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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