Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1284210	0.1015248	0.2197566
Weighted median	23	-0.0875584	0.0513733	0.0883145
Inverse variance weighted	23	-0.0480743	0.0394412	0.2228874
Simple mode	23	-0.0345574	0.0840665	0.6849965
Weighted mode	23	-0.0862999	0.0598489	0.1633980

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.47753	21	0.4301327
Inverse variance weighted	22.23356	22	0.4460241

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0049337	0.0057383	0.3996212

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007192	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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