Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0520424	0.1012237	0.6125277
Weighted median	23	-0.0204888	0.0593416	0.7298922
Inverse variance weighted	23	-0.0600920	0.0399606	0.1326374
Simple mode	23	-0.0752818	0.0963649	0.4430016
Weighted mode	23	-0.0308004	0.0719646	0.6728161

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.35028	21	0.4377385
Inverse variance weighted	22.82286	22	0.4117893

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0068855	0.0057212	0.2421741

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007627	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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