Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0799625	0.1248595	0.5288262
Weighted median	23	-0.0772572	0.0560246	0.1678989
Inverse variance weighted	23	-0.0311608	0.0478790	0.5151602
Simple mode	23	0.0955620	0.1066424	0.3799012
Weighted mode	23	-0.0937478	0.0617624	0.1432853

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	32.48543	21	0.0522435
Inverse variance weighted	32.76435	22	0.0652664

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029967	0.0070572	0.6754301

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010119	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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