Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0713942	0.1192916	0.5559173
Weighted median	23	-0.0026207	0.0573612	0.9635586
Inverse variance weighted	23	0.0110527	0.0458754	0.8096098
Simple mode	23	0.1997738	0.1112877	0.0863877
Weighted mode	23	-0.0052039	0.0666201	0.9384447

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.65266	21	0.0991931
Inverse variance weighted	30.07908	22	0.1165549

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0037052	0.0067425	0.588434

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009139	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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