Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1725566	0.1170207	0.1551601
Weighted median	23	-0.1138893	0.0627888	0.0697015
Inverse variance weighted	23	-0.0578054	0.0458733	0.2076291
Simple mode	23	-0.0702326	0.1084743	0.5240347
Weighted mode	23	-0.0667099	0.0766259	0.3933777

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.53481	21	0.1256251
Inverse variance weighted	30.07695	22	0.1166060

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0070463	0.0066141	0.2988224

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009772	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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