Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD slf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0091333	0.1231672	0.9415902
Weighted median	23	0.0001712	0.0569972	0.9976041
Inverse variance weighted	23	-0.0024296	0.0470404	0.9588076
Simple mode	23	-0.0356726	0.0975336	0.7180475
Weighted mode	23	-0.0113030	0.0659197	0.8654249

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.61081	21	0.064076
Inverse variance weighted	31.62647	22	0.083991

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.00071	0.0069615	0.9197313

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009584	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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