Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0638368	0.1122120	0.5754622
Weighted median	23	-0.0711250	0.0556412	0.2011510
Inverse variance weighted	23	-0.1499729	0.0435494	0.0005737
Simple mode	23	-0.1146681	0.1038846	0.2816062
Weighted mode	23	-0.0947025	0.0669815	0.1713982

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.23816	21	0.1975131
Inverse variance weighted	27.10710	22	0.2071870

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0052891	0.0063423	0.4136988

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012641	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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