Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0900039	0.1071425	0.4103489
Weighted median	23	-0.1238765	0.0537406	0.0211620
Inverse variance weighted	23	-0.1275772	0.0410511	0.0018851
Simple mode	23	-0.1254470	0.0925361	0.1889635
Weighted mode	23	-0.1162913	0.0607884	0.0688453

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.92071	21	0.2969161
Inverse variance weighted	24.08605	22	0.3427350

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0023072	0.0060558	0.7070414

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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