Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1158576	0.1224477	0.3548177
Weighted median	23	0.0478391	0.0591136	0.4183580
Inverse variance weighted	23	0.0861516	0.0468312	0.0658239
Simple mode	23	0.0573361	0.0990646	0.5686204
Weighted mode	23	0.0612926	0.0675409	0.3739814

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.24299	21	0.0697079
Inverse variance weighted	31.34634	22	0.0892432

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0018241	0.0069209	0.7946861

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010959	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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