Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0429424	0.1282405	0.7410539
Weighted median	23	0.0719868	0.0631186	0.2540778
Inverse variance weighted	23	0.0609173	0.0489927	0.2137223
Simple mode	23	0.2355221	0.1051041	0.0354564
Weighted mode	23	0.1003176	0.0758220	0.1994005

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.26891	21	0.0339078
Inverse variance weighted	34.30675	22	0.0457063

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0011037	0.0072483	0.8804226

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011126	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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