Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1523116	0.1015510	0.1485372
Weighted median	23	-0.0036945	0.0577839	0.9490203
Inverse variance weighted	23	-0.0180872	0.0406340	0.6562296
Simple mode	23	0.0571104	0.1051752	0.5925877
Weighted mode	23	0.0084584	0.0759688	0.9123561

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	21.48928	21	0.4294333
Inverse variance weighted	23.59926	22	0.3685802

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0082421	0.0057398	0.1657478

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007215	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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