Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ilf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0061023	0.1418218	0.9660856
Weighted median	23	-0.0955824	0.0597122	0.1094393
Inverse variance weighted	23	-0.0992980	0.0548042	0.0700063
Simple mode	23	-0.1168241	0.1009345	0.2595110
Weighted mode	23	-0.0936431	0.0685411	0.1856698

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	41.91169	21	0.0043166
Inverse variance weighted	42.92888	22	0.0048151

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0057226	0.0080159	0.4831437

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0014947	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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