Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1438723	0.1201641	0.2445312
Weighted median	23	-0.1303379	0.0587743	0.0265821
Inverse variance weighted	23	-0.1310105	0.0458966	0.0043108
Simple mode	23	-0.1507328	0.1017024	0.1524975
Weighted mode	23	-0.1264346	0.0652231	0.0654992

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	30.08854	21	0.0902231
Inverse variance weighted	30.10792	22	0.1158650

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0007898	0.0067918	0.9085328

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012502	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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