Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0000396	0.1124275	0.9997225
Weighted median	23	-0.0536390	0.0598025	0.3697531
Inverse variance weighted	23	-0.0812779	0.0435545	0.0620248
Simple mode	23	0.0334906	0.1009656	0.7432527
Weighted mode	23	-0.0525991	0.0690185	0.4540928

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.33880	21	0.1938239
Inverse variance weighted	27.11323	22	0.2069574

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0049933	0.0063545	0.440772

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009516	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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