Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0004196	0.1160970	0.9971504
Weighted median	23	-0.1046745	0.0596619	0.0793516
Inverse variance weighted	23	-0.0753029	0.0448445	0.0931132
Simple mode	23	0.0239969	0.0966846	0.8062832
Weighted mode	23	-0.0856664	0.0639890	0.1943168

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	28.08626	21	0.1377218
Inverse variance weighted	28.74298	22	0.1523461

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0045982	0.0065619	0.4911598

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009826	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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