Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0353319	0.1003897	0.7283847
Weighted median	23	-0.0440719	0.0578306	0.4460087
Inverse variance weighted	23	-0.0488840	0.0392336	0.2127738
Simple mode	23	-0.0645202	0.0953522	0.5056801
Weighted mode	23	-0.0586207	0.0718761	0.4234829

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.02553	21	0.5835022
Inverse variance weighted	19.04704	22	0.6424219

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0008322	0.0056741	0.8848002

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006242	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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