Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1402136	0.1276287	0.2843767
Weighted median	23	-0.0400094	0.0598163	0.5035782
Inverse variance weighted	23	-0.0222679	0.0498878	0.6553369
Simple mode	23	0.0373854	0.1054560	0.7263307
Weighted mode	23	-0.0465204	0.0793592	0.5637077

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	33.94368	21	0.0367454
Inverse variance weighted	35.57293	22	0.0337220

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0072425	0.0072138	0.3268189

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010875	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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