Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1060538	0.1003906	0.3027821
Weighted median	23	-0.0272348	0.0540797	0.6145391
Inverse variance weighted	23	0.0239787	0.0392339	0.5410844
Simple mode	23	0.1519442	0.0968831	0.1310773
Weighted mode	23	-0.0386603	0.0593696	0.5216744

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	12.71800	21	0.9181797
Inverse variance weighted	14.69815	22	0.8748628

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0079846	0.0056742	0.1740033

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0004567	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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