Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0013685	0.1070076	0.9899172
Weighted median	23	0.0229276	0.0552168	0.6779749
Inverse variance weighted	23	0.0381574	0.0409938	0.3519531
Simple mode	23	0.0546240	0.0871938	0.5374559
Weighted mode	23	0.0045128	0.0634879	0.9439748

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.85964	21	0.2999088
Inverse variance weighted	24.01814	22	0.3462790

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.002259	0.0060482	0.7125194

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007564	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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