Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD cgh r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1298285	0.1003898	0.2099726
Weighted median	23	-0.0324551	0.0585159	0.5791434
Inverse variance weighted	23	0.0005590	0.0392336	0.9886311
Simple mode	23	-0.1234689	0.1083994	0.2669468
Weighted mode	23	-0.0339269	0.0666644	0.6158744

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	16.55003	21	0.7379949
Inverse variance weighted	18.54105	22	0.6734713

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0080064	0.0056741	0.1728787

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005619	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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