Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD cgh l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1040158	0.1003907	0.3119350
Weighted median	23	0.0108694	0.0552183	0.8439500
Inverse variance weighted	23	-0.0110148	0.0392338	0.7789042
Simple mode	23	-0.0548027	0.0875507	0.5377858
Weighted mode	23	0.0187922	0.0594947	0.7550839

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.53195	21	0.5510560
Inverse variance weighted	21.08156	22	0.5157028

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0070634	0.0056742	0.2269076

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006412	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8