Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD cgc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1096216	0.1524667	0.4800734
Weighted median	23	-0.0999637	0.0620533	0.1071945
Inverse variance weighted	23	-0.0402917	0.0597764	0.5002851
Simple mode	23	-0.3237978	0.1463219	0.0375841
Weighted mode	23	-0.1832265	0.1104197	0.1112321

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	48.44043	21	0.0005988
Inverse variance weighted	51.07251	22	0.0004192

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0092054	0.0086176	0.2975534

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0015795	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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