Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD cgc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0730322	0.1339016	0.5912137
Weighted median	23	-0.0532031	0.0632023	0.3999049
Inverse variance weighted	23	-0.0767067	0.0511281	0.1335408
Simple mode	23	-0.1561903	0.1211091	0.2105603
Weighted mode	23	0.0278881	0.0814212	0.7352129

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.36173	21	0.0152936
Inverse variance weighted	37.36331	22	0.0215728

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002256	0.0075683	0.9764974

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012479	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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