Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD atr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0653862	0.1003896	0.5219016
Weighted median	23	-0.0074546	0.0563453	0.8947459
Inverse variance weighted	23	-0.0473470	0.0392893	0.2281694
Simple mode	23	-0.0365436	0.0976777	0.7118936
Weighted mode	23	0.0021042	0.0698981	0.9762558

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.57403	21	0.4852072
Inverse variance weighted	22.06239	22	0.4561701

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0069223	0.0056741	0.2359953

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007127	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8