Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD atr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1073611	0.1075120	0.3293585
Weighted median	23	0.0374976	0.0577268	0.5159702
Inverse variance weighted	23	-0.0713266	0.0441228	0.1059764
Simple mode	23	-0.1061058	0.0992867	0.2968001
Weighted mode	23	0.0312203	0.0739225	0.6768769

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.08585	21	0.2889174
Inverse variance weighted	27.82523	22	0.1815459

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0109722	0.0060767	0.0853335

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0009432	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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