Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ar r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1611244	0.1099513	0.1576204
Weighted median	23	-0.0612536	0.0571509	0.2838156
Inverse variance weighted	23	-0.0408187	0.0433720	0.3466381
Simple mode	23	-0.0700651	0.0998251	0.4901142
Weighted mode	23	-0.0730396	0.0642098	0.2675612

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.19118	21	0.2389790
Inverse variance weighted	26.88623	22	0.2155797

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0073873	0.0062145	0.2478222

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008475	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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