Two sample MR report

Telomere_length against IDP dMRI ProbtrackX OD ar l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1145157	0.1069963	0.2966422
Weighted median	23	-0.0036479	0.0554280	0.9475269
Inverse variance weighted	23	-0.0163847	0.0425379	0.7001049
Simple mode	23	-0.0190937	0.0881973	0.8306018
Weighted mode	23	0.0095291	0.0594048	0.8740225

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.85515	21	0.3001300
Inverse variance weighted	25.86187	22	0.2576597

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0080379	0.0060475	0.1980702

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000789	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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