Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO unc r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0765728	0.1003883	0.4540864
Weighted median	23	0.0375269	0.0546846	0.4925601
Inverse variance weighted	23	-0.0133446	0.0392330	0.7337523
Simple mode	23	0.0448723	0.0858016	0.6062176
Weighted mode	23	0.0534152	0.0601003	0.3837424

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.11165	21	0.5141994
Inverse variance weighted	21.05855	22	0.5171224

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0055213	0.005674	0.3415869

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006416	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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