Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO unc l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1204539	0.1003878	0.2435461
Weighted median	23	0.0528282	0.0573156	0.3566809
Inverse variance weighted	23	0.0151892	0.0392327	0.6986403
Simple mode	23	0.0679316	0.1012871	0.5094023
Weighted mode	23	0.0651527	0.0751187	0.3951235

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	19.21585	21	0.5712954
Inverse variance weighted	20.51358	22	0.5509474

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0064638	0.0056741	0.2674571

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0006261	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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