Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO str r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0485681	0.1285441	0.7093472
Weighted median	23	0.0742151	0.0620456	0.2316428
Inverse variance weighted	23	0.0449908	0.0490834	0.3593420
Simple mode	23	-0.1073777	0.1269869	0.4068895
Weighted mode	23	0.1182028	0.0748145	0.1283911

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	34.43408	21	0.0325433
Inverse variance weighted	34.43558	22	0.0443345

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0002197	0.0072655	0.9761659

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010833	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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