Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO str l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0067103	0.1333554	0.9603441
Weighted median	23	0.0132862	0.0594206	0.8230720
Inverse variance weighted	23	-0.0023504	0.0509209	0.9631849
Simple mode	23	-0.0428120	0.1164629	0.7166826
Weighted mode	23	0.0741409	0.0667787	0.2788804

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	37.05930	21	0.0165721
Inverse variance weighted	37.06153	22	0.0232907

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0002677	0.0075374	0.9720017

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011232	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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