Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO slf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0076584	0.1227701	0.9508499
Weighted median	23	-0.0506155	0.0572917	0.3769823
Inverse variance weighted	23	-0.0523504	0.0471905	0.2672826
Simple mode	23	-0.1328617	0.0936580	0.1700322
Weighted mode	23	-0.0537612	0.0636977	0.4077513

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	31.40814	21	0.0671286
Inverse variance weighted	31.82988	22	0.0803430

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0036848	0.0069391	0.6009752

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0010184	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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