Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO slf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0312497	0.1442247	0.8305538
Weighted median	23	-0.0216695	0.0585196	0.7111624
Inverse variance weighted	23	-0.0468966	0.0550873	0.3945950
Simple mode	23	-0.2124294	0.1106730	0.0679923
Weighted mode	23	-0.0105518	0.0593001	0.8603992

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	43.34548	21	0.0028393
Inverse variance weighted	43.37415	22	0.0042430

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0009608	0.0081517	0.907296

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0013576	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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