Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ptr r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0678809	0.1186612	0.5733572
Weighted median	23	0.1076814	0.0611185	0.0780952
Inverse variance weighted	23	0.0897645	0.0475024	0.0588005
Simple mode	23	0.1552557	0.1211631	0.2134032
Weighted mode	23	0.0494286	0.0786597	0.5362217

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	29.34154	21	0.1060403
Inverse variance weighted	32.25218	22	0.0731970

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0096802	0.0067069	0.1636826

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011359	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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