Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ptr l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1322583	0.1003880	0.2018749
Weighted median	23	0.0394346	0.0541755	0.4666722
Inverse variance weighted	23	0.0517674	0.0392330	0.1870063
Simple mode	23	0.1060045	0.0941559	0.2723650
Weighted mode	23	0.0854069	0.0726221	0.2521461

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	11.69226	21	0.9475554
Inverse variance weighted	15.65846	22	0.8324675

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0113	0.005674	0.0595884

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0005272	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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