Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ml r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0049267	0.1383287	0.9719252
Weighted median	23	-0.0022638	0.0572272	0.9684459
Inverse variance weighted	23	-0.0525277	0.0530729	0.3223082
Simple mode	23	0.0060427	0.0991985	0.9519766
Weighted mode	23	-0.0030109	0.0692933	0.9657334

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	39.87349	21	0.0077046
Inverse variance weighted	40.26009	22	0.0100795

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0035279	0.0078184	0.6564471

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0012742	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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