Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ml l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0740022	0.1367495	0.5940983
Weighted median	23	-0.0717272	0.0623048	0.2496368
Inverse variance weighted	23	-0.0320523	0.0530907	0.5460247
Simple mode	23	-0.1055692	0.1137000	0.3632299
Weighted mode	23	-0.0936461	0.1040771	0.3779833

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	38.97122	21	0.0098933
Inverse variance weighted	40.28861	22	0.0100020

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0065123	0.0077293	0.4089752

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.001241	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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