Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO mcp

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1828965	0.1003871	0.0827434
Weighted median	23	0.0028309	0.0570198	0.9604039
Inverse variance weighted	23	0.0043704	0.0414434	0.9160144
Simple mode	23	-0.0306852	0.0958235	0.7518186
Weighted mode	23	-0.0030236	0.0772752	0.9691415

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.81658	21	0.4701937
Inverse variance weighted	24.54932	22	0.3191079

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0109624	0.005674	0.0669596

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007442	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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