Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ilf r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0247043	0.1312403	0.8524980
Weighted median	23	0.0222416	0.0577406	0.7000896
Inverse variance weighted	23	0.0404653	0.0501314	0.4195591
Simple mode	23	0.0452157	0.0986296	0.6511333
Weighted mode	23	0.0300993	0.0671429	0.6583297

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.89192	21	0.0224843
Inverse variance weighted	35.92101	22	0.0309633

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0009678	0.0074178	0.8974369

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011207	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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