Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ilf l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0826790	0.1138044	0.4755524
Weighted median	23	0.0548844	0.0511960	0.2837002
Inverse variance weighted	23	0.0533680	0.0435345	0.2202451
Simple mode	23	0.0445729	0.0861281	0.6099590
Weighted mode	23	0.0529228	0.0591601	0.3807003

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	26.98824	21	0.1712427
Inverse variance weighted	27.08886	22	0.2078708

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0017998	0.0064323	0.7823615

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008768	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8