Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ifo r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0591472	0.1054057	0.5806423
Weighted median	23	0.0592043	0.0567515	0.2968465
Inverse variance weighted	23	0.0395541	0.0402858	0.3261798
Simple mode	23	0.0733918	0.0823032	0.3821900
Weighted mode	23	0.0637581	0.0656087	0.3417177

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	23.15157	21	0.3359508
Inverse variance weighted	23.19652	22	0.3907045

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0012031	0.0059577	0.8419049

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007337	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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