Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO ifo l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0863502	0.1106468	0.4438559
Weighted median	23	-0.0987954	0.0587694	0.0927496
Inverse variance weighted	23	-0.0390348	0.0424647	0.3579748
Simple mode	23	-0.0817871	0.1028749	0.4350981
Weighted mode	23	-0.0743236	0.0768871	0.3442219

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.51167	21	0.2256838
Inverse variance weighted	25.77387	22	0.2615176

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0029054	0.0062539	0.6470176

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000811	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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