Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO fmi

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.0095844	0.1003877	0.9248439
Weighted median	23	-0.0732317	0.0564045	0.1941736
Inverse variance weighted	23	-0.0604470	0.0392329	0.1233844
Simple mode	23	-0.0041385	0.0950273	0.9656553
Weighted mode	23	-0.0702964	0.0652172	0.2927640

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	20.71898	21	0.4762170
Inverse variance weighted	21.02196	22	0.5193812

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0031232	0.005674	0.5878262

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0007089	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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