Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO fma

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	-0.1340871	0.1309421	0.3174788
Weighted median	23	0.0066696	0.0600739	0.9115975
Inverse variance weighted	23	-0.0204092	0.0510454	0.6892859
Simple mode	23	0.0447069	0.1275213	0.7292351
Weighted mode	23	0.0098953	0.0865231	0.9099847

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	35.72938	21	0.0234453
Inverse variance weighted	37.24288	22	0.0222440

Test for directional horizontal pleiotropy

egger_intercept	se	pval
0.0069804	0.007401	0.3563221

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0011367	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8