Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO cst r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1399359	0.1090468	0.2133808
Weighted median	23	-0.0402925	0.0574331	0.4829564
Inverse variance weighted	23	-0.0366687	0.0446005	0.4109866
Simple mode	23	-0.0824295	0.1008773	0.4226174
Weighted mode	23	-0.0596727	0.0691417	0.3974216

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.77906	21	0.2568599
Inverse variance weighted	28.43185	22	0.1618073

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.0108444	0.0061635	0.0930617

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.000888	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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