Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO cst l

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.0609750	0.1081619	0.5789033
Weighted median	23	-0.0406912	0.0564526	0.4710302
Inverse variance weighted	23	-0.0682014	0.0429226	0.1120740
Simple mode	23	-0.0975429	0.0980540	0.3306561
Weighted mode	23	-0.0333077	0.0641357	0.6087153

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	24.37842	21	0.2750867
Inverse variance weighted	26.33269	22	0.2376726

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.007932	0.0061134	0.2085406

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008894	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

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Comparison of results using different MR methods

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Funnel plot

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Leave-one-out sensitivity analysis

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