Two sample MR report

Telomere_length against IDP dMRI ProbtrackX MO cgh r

Date: 22 April, 2022

Results from two sample MR:

method	nsnp	b	se	pval
MR Egger	23	0.1370384	0.1096725	0.2252215
Weighted median	23	-0.0372480	0.0550449	0.4986062
Inverse variance weighted	23	-0.0218588	0.0442776	0.6215350
Simple mode	23	-0.0935758	0.0889527	0.3042301
Weighted mode	23	-0.0500021	0.0607470	0.4192732

Heterogeneity tests

method	Q	Q_df	Q_pval
MR Egger	25.06440	21	0.2443856
Inverse variance weighted	28.02144	22	0.1749719

Test for directional horizontal pleiotropy

egger_intercept	se	pval
-0.009757	0.0061988	0.1304298

Test that the exposure is upstream of the outcome

snp_r2.exposure	snp_r2.outcome	correct_causal_direction	steiger_pval
0.0357937	0.0008585	TRUE	0

Note - R² values are approximate

Forest plot of single SNP MR

plot of chunk chunk5

Comparison of results using different MR methods

plot of chunk chunk6

Funnel plot

plot of chunk chunk7

Leave-one-out sensitivity analysis

plot of chunk chunk8